DNA methylation modifier LSH inhibits p53 ubiquitination and transactivates p53 to promote lipid metabolism.

Ling ChenYing ShiNa LiuZuli WangRui YangBin YanXiaoli LiuWeiwei LaiYating LiuDesheng XiaoHu ZhouYan ChengYa CaoShuang LiuZanxian XiaKonstantin M J Sparrer

Published in: Epigenetics & chromatin (2019)

These findings suggest that LSH is a novel regulator of p53 through the proteasomal pathway, thereby providing an alternative mechanism of p53 involvement in lipid metabolism in cancer.

Keyphrases

dna methylation
papillary thyroid
fatty acid
genome wide
squamous cell
gene expression
transcription factor
squamous cell carcinoma
childhood cancer