DNA methylation modifier LSH inhibits p53 ubiquitination and transactivates p53 to promote lipid metabolism.
Ling ChenYing ShiNa LiuZuli WangRui YangBin YanXiaoli LiuWeiwei LaiYating LiuDesheng XiaoHu ZhouYan ChengYa CaoShuang LiuZanxian XiaKonstantin M J SparrerPublished in: Epigenetics & chromatin (2019)
These findings suggest that LSH is a novel regulator of p53 through the proteasomal pathway, thereby providing an alternative mechanism of p53 involvement in lipid metabolism in cancer.