S-Allylcysteine Potently Protects against PhIP-Induced DNA Damage via Nrf2/AhR Signaling Pathway Modulation in Normal Human Colonic Mucosal Epithelial Cells.

Wei-Sheng LinYing-Jang LaiNagabhushanam KalyanamChi-Tang HoMin-Hsiung Pan

Published in: Molecular nutrition & food research (2022)

Collectively, these findings suggest that SAC protects against PhIP-induced reactive oxygen species production and DNA damage by modulating the Nrf2/AhR signaling pathway, which may have significant potential as a novel chemopreventive agent.

Keyphrases

dna damage
signaling pathway
oxidative stress
diabetic rats
high glucose
reactive oxygen species
endothelial cells
pi k akt
dna repair
epithelial mesenchymal transition
induced apoptosis
drug induced
ulcerative colitis
cell proliferation
climate change