Briarane-Related Diterpenoids from Octocoral Briareum stechei.
Thanh-Hao HuynhChoo-Aun NeohYu-Chi TsaiZhi-Kang YaoLi-Guo ZhengPin-Chang HuangZhi-Hong WenJih-Jung ChenYu-Jen WuPing-Jyun SungPublished in: Molecules (Basel, Switzerland) (2021)
A known polyoxygenated briarane, briaexcavatolide P (1), was isolated from a Formosan octocoral Briareum stechei. Moreover, the same species B. stechei, collected from Okinawan waters, yielded three chlorine-containing briaranes, including two new compounds, briastecholides B (2) and C (3) as well as a known analogue, briarenol R (4). The structures of 1-4 were established using spectroscopic methods. In addition, briarane 1 demonstrated anti-inflammatory activity in lipo-polysaccharide-induced RAW 264.7 mouse macrophage cells by suppressing the expression of inducible nitric oxide synthase (iNOS) protein.
Keyphrases
- nitric oxide synthase
- nitric oxide
- induced apoptosis
- poor prognosis
- cell cycle arrest
- binding protein
- high glucose
- molecular docking
- drinking water
- drug induced
- high resolution
- endoplasmic reticulum stress
- cell death
- protein protein
- oxidative stress
- long non coding rna
- small molecule
- genetic diversity
- cell proliferation