Characteristics and treatment results of refractory and relapsed acute myeloid leukaemia in paediatric patients treated in Polish Paediatric Leukaemia/Lymphoma Study Group institutions according to the Protocol Acute Myeloid Leukaemia Berlin-Frankfurt-Munster 2012 and a review of novel treatment possibilities in paediatric acute myeloid leukaemia.
Magdalena SamborskaJolanta Skalska-SadowskaRobert AchkarJacek WachowiakKatarzyna DerwichMałgorzata CzogałaWalentyna BalwierzSzymon SkoczeńGrzegorz DobaczewskiAlicja ChybickaKrzysztof KałwakMaryna Krawczuk-RybakKatarzyna Muszyńska-RosłanElżbieta Adamkiewicz-DrożyńskaLucyna Maciejka-KapuscińskaNinela Irga-JaworskaJoanna PohoreckaAgnieszka Chodała-GrzywaczGrażyna KarolczykBeata WójcikJerzy R KowalczykKatarzyna DrabkoJoanna ZawitkowskaKatarzyna MyckoWanda BadowskaTomasz OciepaTomasz UrasińskiBarbara Sikorska-FicMichał MatysiakPaweł LagunaAnna Dąbrowska-PawliszynRenata TomaszewskaTomasz SzczepańskiGrażyna SobolAgnieszka Mizia-MalarzMałgorzata CiebieraRadosław ChaberSylwia KołtanMariusz WysockiJan StyczyńskiMariola WoszczykMaria WieczorekIrena Karpińska-DerdaJustyna Urbańska-RakusKatarzyna BobeffJoanna TrelińskaWojciech MłynarskiPublished in: Contemporary oncology (Poznan, Poland) (2024)
The prognosis of refractory AML and the first AML recurrence in children who were first-line treated in PPL/LSG centres according to Protocol Acute Myeloid Leukaemia Berlin-Frankfurt-Munster 2012 is poor. Failures of re-induction treatment particularly result from difficulties in achieving remission. Allogeneic HSCT improves prognosis in children with refractory and first recurrent AML, under the condition it is performed in complete remission. Novel therapeutic approaches are needed to increase the remission rate and improve the outcomes.
Keyphrases
- acute myeloid leukemia
- liver failure
- bone marrow
- respiratory failure
- intensive care unit
- emergency department
- young adults
- drug induced
- randomized controlled trial
- aortic dissection
- diffuse large b cell lymphoma
- hepatitis b virus
- allogeneic hematopoietic stem cell transplantation
- low dose
- multiple myeloma
- acute lymphoblastic leukemia
- metabolic syndrome
- combination therapy
- replacement therapy
- insulin resistance
- newly diagnosed
- hodgkin lymphoma
- adipose tissue
- mechanical ventilation