Integrated multidisciplinarity in the natural sciences.
Angela M GronenbornPublished in: The Journal of biological chemistry (2019)
The integration of multiple perspectives in both the arts and natural sciences is tremendously powerful and arguably necessary for capturing relevant features of complex phenomena. Individual methods and models comprise abstractions from and idealizations of nature, and only the integration of multiple models, methods, and representations provides a means to reach more accurate results than relying on any single approach. In my Mildred Cohn Award Lecture at the 2019 ASBMB meeting, I illustrated the power of such multidisciplinary work by highlighting the successful integration of data and multiple views afforded by NMR spectroscopy, cryo-electron microscopy, cryo-electron tomography, X-ray crystallography, computation, and functional assays made possible through collaborative efforts by members of the Pittsburgh Center for HIV Protein Interactions. This approach permitted us to generate the first all-atom model of a native HIV-1 capsid core.
Keyphrases
- electron microscopy
- antiretroviral therapy
- hiv positive
- hiv infected
- human immunodeficiency virus
- hiv testing
- quality improvement
- hepatitis c virus
- high resolution
- hiv aids
- men who have sex with men
- working memory
- high throughput
- electronic health record
- big data
- magnetic resonance imaging
- machine learning
- small molecule
- data analysis
- single cell