Hepatic arterial chemotherapy with raltitrexed and oxaliplatin versus standard chemotherapy in unresectable liver metastases from colorectal cancer after conventional chemotherapy failure (HEARTO): a randomized phase-II study.

François GhiringhelliJulie VincentLeila BengrineChristophe BorgJean Louis JouveRomaric LoffroyBoris GuiuJulie BlancAurélie Bertaut

Published in: Journal of cancer research and clinical oncology (2019)

Although stopped prematurely, this randomized trial provides evidence for the benefit and safety of HAI of a combination of raltitrexed and oxaliplatin in liver-only mCRC with chemoresistant disease.

Keyphrases

locally advanced
phase ii study
liver metastases
rectal cancer
squamous cell carcinoma
radiation therapy
randomized controlled trial
open label
clinical trial
chemotherapy induced