Primary allogeneic mitochondrial mix (PAMM) transfer/transplant by MitoCeption to address damage in PBMCs caused by ultraviolet radiation.

Francisco CabreraMayra OrtegaFrancesca VelardeEliseo ParraStephany GallardoDiego BarbaLina SotoGabriela PeñaLuis Alberto PedrozaChristian JorgensenMaroun KhouryAndrés Caicedo

Published in: BMC biotechnology (2019)

Our results represent an advancement in the applications of MitoCeption and other AMT/T. We showed that PBMCs could be used as a PAMM source of mitochondria. We also showed that these mitochondria can be transferred in a mix from different donors (PAMM) to UVR-damaged, non-adherent primary cells. Additionally, we decreased the duration of the MitoCeption protocol.

Keyphrases

oxidative stress
induced apoptosis
cell death
cell cycle arrest
stem cell transplantation
randomized controlled trial
reactive oxygen species
bone marrow
endoplasmic reticulum
radiation therapy
endoplasmic reticulum stress
low dose
cell proliferation