Sulfonamide Synthesis via Calcium Triflimide Activation of Sulfonyl Fluorides.
Paramita MukherjeeCristian P WorochLeah ClearyMark RusznakRyan W FranzeseMatthew R ReeseJoseph W TuckerJohn M HumphreySarah M EtukSabrina C KwanChristopher W Am EndeNicholas D BallPublished in: Organic letters (2018)
A method using calcium triflimide [Ca(NTf2)2] as a Lewis acid to activate sulfonyl fluorides toward nucleophilic addition with amines is described. The reaction converts a wide array of sterically and electronically diverse sulfonyl fluorides and amines into the corresponding sulfonamides in good yield.