Christopher W Am Ende

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 28

Top Venues

Journal of the American Chemical Society

Nature structural & molecular biology

Journal of medicinal chemistry

Organic letters

This page only lists publications with an associated author ORCID identifier.

Publications

Fabian Offensperger, Gary Tin, Miquel Duran-Frigola, Elisa Hahn, Sarah Dobner, Christopher W Am Ende, Joseph W Strohbach, Andrea Rukavina, Vincenth Brennsteiner, Kevin Ogilvie, Chakravarthy B N Marella, Katharina Kladnik, Rodolfo Ciuffa, Jaimeen D Majmudar, S Denise Field, Ariel Bensimon, Luca Ferrari, Evandro Ferrada, Amanda Ng, Zhechun Zhang, Gianluca Degliesposti, Andras Boeszoermenyi, Sascha Martens, Robert Stanton, André C Müller, J Thomas Hannich, David Hepworth, Giulio Superti-Furga, Stefan Kubicek, Monica Schenone, Georg E Winter
Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science (New York, N.Y.) 384 (6694) (2024)
Martin Pettersson, Douglas S Johnson, John M Humphrey, Christopher W Am Ende, Todd W Butler, Peter H Dorff, Ivan V Efremov, Edelweiss Evrard, Michael E Green, Christopher J Helal, Gregory W Kauffman, Patrick B Mullins, Thayalan Navaratnam, Christopher J O'Donnell, Theresa J O'Sullivan, Nandini C Patel, Antonia F Stepan, Cory M Stiff, Chakrapani Subramanyam, Patrick Trapa, Tuan P Tran, Beth Cooper Vetelino, Eddie Yang, Longfei Xie, Leslie R Pustilnik, Stefanus J Steyn, Kathleen M Wood, Kelly R Bales, Eva Hajos-Korcsok, Patrick R Verhoest
Discovery of Clinical Candidate PF-06648671: A Potent γ-Secretase Modulator for the Treatment of Alzheimer's Disease. Journal of medicinal chemistry 67 (12) (2024)
Martin Pettersson, Douglas S Johnson, John M Humphrey, Christopher W Am Ende, Todd W Butler, Peter H Dorff, Ivan V Efremov, Edelweiss Evrard, Michael E Green, Christopher J Helal, Gregory W Kauffman, Patrick B Mullins, Thayalan Navaratnam, Christopher J O'Donnell, Theresa J O'Sullivan, Nandini C Patel, Antonia F Stepan, Cory M Stiff, Chakrapani Subramanyam, Patrick Trapa, Tuan P Tran, Beth Cooper Vetelino, Eddie Yang, Longfei Xie, Leslie R Pustilnik, Stefanus J Steyn, Kathleen M Wood, Kelly R Bales, Eva Hajos-Korcsok, Patrick R Verhoest
Discovery of Clinical Candidate PF-06648671: A Potent γ-Secretase Modulator for the Treatment of Alzheimer's Disease. Journal of medicinal chemistry (2024)
Fabian Offensperger, Gary Tin, Miquel Duran-Frigola, Elisa Hahn, Sarah Dobner, Christopher W Am Ende, Joseph W Strohbach, Andrea Rukavina, Vincenth Brennsteiner, Kevin Ogilvie, Chakravarthy B N Marella, Katharina Kladnik, Rodolfo Ciuffa, Jaimeen D Majmudar, S Denise Field, Ariel Bensimon, Luca Ferrari, Evandro Ferrada, Amanda Ng, Zhechun Zhang, Gianluca Degliesposti, Andras Boeszoermenyi, Sascha Martens, Robert Stanton, André C Müller, J Thomas Hannich, David Hepworth, Giulio Superti-Furga, Stefan Kubicek, Monica Schenone, Georg E Winter
Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science (New York, N.Y.) 384 (6694) (2024)
Martin Pettersson, Douglas S Johnson, John M Humphrey, Christopher W Am Ende, Todd W Butler, Peter H Dorff, Ivan V Efremov, Edelweiss Evrard, Michael E Green, Christopher J Helal, Gregory W Kauffman, Patrick B Mullins, Thayalan Navaratnam, Christopher J O'Donnell, Theresa J O'Sullivan, Nandini C Patel, Antonia F Stepan, Cory M Stiff, Chakrapani Subramanyam, Patrick Trapa, Tuan P Tran, Beth Cooper Vetelino, Eddie Yang, Longfei Xie, Leslie R Pustilnik, Stefanus J Steyn, Kathleen M Wood, Kelly R Bales, Eva Hajos-Korcsok, Patrick R Verhoest
Discovery of Clinical Candidate PF-06648671: A Potent γ-Secretase Modulator for the Treatment of Alzheimer's Disease. Journal of medicinal chemistry 67 (12) (2024)
Fabian Offensperger, Gary Tin, Miquel Duran-Frigola, Elisa Hahn, Sarah Dobner, Christopher W Am Ende, Joseph W Strohbach, Andrea Rukavina, Vincenth Brennsteiner, Kevin Ogilvie, Chakravarthy B N Marella, Katharina Kladnik, Rodolfo Ciuffa, Jaimeen D Majmudar, S Denise Field, Ariel Bensimon, Luca Ferrari, Evandro Ferrada, Amanda Ng, Zhechun Zhang, Gianluca Degliesposti, Andras Boeszoermenyi, Sascha Martens, Robert Stanton, André C Müller, J Thomas Hannich, David Hepworth, Giulio Superti-Furga, Stefan Kubicek, Monica Schenone, Georg E Winter
Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science (New York, N.Y.) 384 (6694) (2024)
Jordan M Mattheisen, Chris Limberakis, Roger B Ruggeri, Matthew S Dowling, Christopher W Am Ende, Emilie Ceraudo, Thomas Huber, Christopher L McClendon, Thomas P Sakmar
Bioorthogonal Tethering Enhances Drug Fragment Affinity for G Protein-Coupled Receptors in Live Cells. Journal of the American Chemical Society (2023)
Amanda M Tallon, Yingrong Xu, Graham M West, Christopher W Am Ende, Joseph M Fox
Thiomethyltetrazines Are Reversible Covalent Cysteine Warheads Whose Dynamic Behavior can be "Switched Off" via Bioorthogonal Chemistry Inside Live Cells. Journal of the American Chemical Society (2023)
Zachary Lee Johnson, Mark Ammirati, David Jonathan Wasilko, Jeanne S Chang, Stephen Noell, Timothy L Foley, Hyejin Yoon, Kathleen Smith, Shoh Asano, Katherine Hales, Min Wan, Qingyi Yang, Mary A Piotrowski, Kathleen A Farley, Tamara Gilbert, Lisa M Aschenbrenner, Kimberly F Fennell, Jason K Dutra, Mary Xu, Chunyang Guo, Alison E Varghese, Justin Bellenger, Alandra Quinn, Christopher W Am Ende, Graham M West, Matthew C Griffor, Donald Bennett, Matthew F Calabrese, Claire M Steppan, Seungil Han, Huixian Wu
Structural basis of the acyl-transfer mechanism of human GPAT1. Nature structural & molecular biology 30 (1) (2022)
Jeroen B I Sap, Claudio F Meyer, Joseph Ford, Natan J W Straathof, Alexander B Dürr, Mariah J Lelos, Stephen James Paisey, Tim A Mollner, Sandrine M Hell, Andrés A Trabanco, Christophe Genicot, Christopher W Am Ende, Robert S Paton, Matthew Tredwell, Véronique Gouverneur
[ 18 F]Difluorocarbene for positron emission tomography. Nature 606 (7912) (2022)
Zachary Lee Johnson, Mark Ammirati, David Jonathan Wasilko, Jeanne S Chang, Stephen Noell, Timothy L Foley, Hyejin Yoon, Kathleen Smith, Shoh Asano, Katherine Hales, Min Wan, Qingyi Yang, Mary A Piotrowski, Kathleen A Farley, Tamara Gilbert, Lisa M Aschenbrenner, Kimberly F Fennell, Jason K Dutra, Mary Xu, Chunyang Guo, Alison E Varghese, Justin Bellenger, Alandra Quinn, Christopher W Am Ende, Graham M West, Matthew C Griffor, Donald Bennett, Matthew F Calabrese, Claire M Steppan, Seungil Han, Huixian Wu
Structural basis of the acyl-transfer mechanism of human GPAT1. Nature structural & molecular biology 30 (1) (2022)
Zachary Lee Johnson, Mark Ammirati, David Jonathan Wasilko, Jeanne S Chang, Stephen Noell, Timothy L Foley, Hyejin Yoon, Kathleen Smith, Shoh Asano, Katherine Hales, Min Wan, Qingyi Yang, Mary A Piotrowski, Kathleen A Farley, Tamara Gilbert, Lisa M Aschenbrenner, Kimberly F Fennell, Jason K Dutra, Mary Xu, Chunyang Guo, Alison E Varghese, Justin Bellenger, Alandra Quinn, Christopher W Am Ende, Graham M West, Matthew C Griffor, Donald Bennett, Matthew F Calabrese, Claire M Steppan, Seungil Han, Huixian Wu
Structural basis of the acyl-transfer mechanism of human GPAT1. Nature structural & molecular biology 30 (1) (2022)
Andrew Jemas, Yixin Xie, Jessica E Pigga, Jeffrey L Caplan, Christopher W Am Ende, Joseph M Fox
Catalytic Activation of Bioorthogonal Chemistry with Light (CABL) Enables Rapid, Spatiotemporally Controlled Labeling and No-Wash, Subcellular 3D-Patterning in Live Cells Using Long Wavelength Light. Journal of the American Chemical Society 144 (4) (2022)
Zachary Lee Johnson, Mark Ammirati, David Jonathan Wasilko, Jeanne S Chang, Stephen Noell, Timothy L Foley, Hyejin Yoon, Kathleen Smith, Shoh Asano, Katherine Hales, Min Wan, Qingyi Yang, Mary A Piotrowski, Kathleen A Farley, Tamara Gilbert, Lisa M Aschenbrenner, Kimberly F Fennell, Jason K Dutra, Mary Xu, Chunyang Guo, Alison E Varghese, Justin Bellenger, Alandra Quinn, Christopher W Am Ende, Graham M West, Matthew C Griffor, Donald Bennett, Matthew F Calabrese, Claire M Steppan, Seungil Han, Huixian Wu
Structural basis of the acyl-transfer mechanism of human GPAT1. Nature structural & molecular biology 30 (1) (2022)
Zachary Lee Johnson, Mark Ammirati, David Jonathan Wasilko, Jeanne S Chang, Stephen Noell, Timothy L Foley, Hyejin Yoon, Kathleen Smith, Shoh Asano, Katherine Hales, Min Wan, Qingyi Yang, Mary A Piotrowski, Kathleen A Farley, Tamara Gilbert, Lisa M Aschenbrenner, Kimberly F Fennell, Jason K Dutra, Mary Xu, Chunyang Guo, Alison E Varghese, Justin Bellenger, Alandra Quinn, Christopher W Am Ende, Graham M West, Matthew C Griffor, Donald Bennett, Matthew F Calabrese, Claire M Steppan, Seungil Han, Huixian Wu
Structural basis of the acyl-transfer mechanism of human GPAT1. Nature structural & molecular biology (2022)
Jessica G K O'Brien, Andrew Jemas, Papa Nii Asare-Okai, Christopher W Am Ende, Joseph M Fox
Probing the Mechanism of Photoaffinity Labeling by Dialkyldiazirines through Bioorthogonal Capture of Diazoalkanes. Organic letters 22 (24) (2020)
Jeroen B I Sap, Natan J W Straathof, Thomas Knauber, Claudio F Meyer, Maurice Médebielle, Laura Buglioni, Christophe Genicot, Andres A Trabanco, Timothy Noël, Christopher W Am Ende, Véronique Gouverneur
Organophotoredox Hydrodefluorination of Trifluoromethylarenes with Translational Applicability to Drug Discovery. Journal of the American Chemical Society 142 (20) (2020)
S Denise Field, Wankyu Lee, Jason K Dutra, Finley Scott F Serneo, Jon Oyer, Hua Xu, Douglas S Johnson, Christopher W Am Ende, Uthpala Seneviratne
Fluorophosphonate-Based Degrader Identifies Degradable Serine Hydrolases by Quantitative Proteomics. Chembiochem : a European journal of chemical biology 21 (20) (2020)
Subham Mahapatra, Cristian P Woroch, Todd W Butler, Sabrina N Carneiro, Sabrina C Kwan, Samuel R Khasnavis, Junha Gu, Jason K Dutra, Beth C Vetelino, Justin Bellenger, Christopher W Am Ende, Nicholas D Ball
SuFEx Activation with Ca(NTf2)2: A Unified Strategy to Access Sulfamides, Sulfamates, and Sulfonamides from S(VI) Fluorides. Organic letters 22 (11) (2020)
William D Lambert, Yinzhi Fang, Subham Mahapatra, Zhen Huang, Christopher W Am Ende, Joseph M Fox
Installation of Minimal Tetrazines through Silver-Mediated Liebeskind-Srogl Coupling with Arylboronic Acids. Journal of the American Chemical Society 141 (43) (2019)
Zhen Huang, Daisuke Ogasawara, Uthpala I Seneviratne, Armand B Cognetta, Christopher W Am Ende, Deane M Nason, Kimberly Lapham, John Litchfield, Douglas S Johnson, Benjamin F Cravatt
Global Portrait of Protein Targets of Metabolites of the Neurotoxic Compound BIA 10-2474. ACS chemical biology 14 (2) (2019)
Samuel L Scinto, Oshini Ekanayake, Uthpala Seneviratne, Jessica E Pigga, Samantha J Boyd, Michael T Taylor, Jun Liu, Christopher W Am Ende, Sharon Rozovsky, Joseph M Fox
Dual-Reactivity trans-Cyclooctenol Probes for Sulfenylation in Live Cells Enable Temporal Control via Bioorthogonal Quenching. Journal of the American Chemical Society 141 (28) (2019)
Longfei Xie, Christopher W Am Ende, Martin Pettersson, Danica A Rankic, Neal W Sach, Subbas Sakya, John M Humphrey
Synthesis of Pyridopyrazine-1,6-dione γ-Secretase Modulators via Selective 4-Methylimidazole N1-Buchwald Arylation. The Journal of organic chemistry 84 (8) (2019)
Paramita Mukherjee, Cristian P Woroch, Leah Cleary, Mark Rusznak, Ryan W Franzese, Matthew R Reese, Joseph W Tucker, John M Humphrey, Sarah M Etuk, Sabrina C Kwan, Christopher W Am Ende, Nicholas D Ball
Sulfonamide Synthesis via Calcium Triflimide Activation of Sulfonyl Fluorides. Organic letters 20 (13) (2018)
Ethan L Fisher, Christopher W Am Ende, John M Humphrey
2,2,2-Trifluoroethoxy Aromatic Heterocycles: Hydrolytically Stable Alternatives to Heteroaryl Chlorides. The Journal of organic chemistry 84 (8) (2018)
Hua Zhou, Paramita Mukherjee, Rongqiang Liu, Edelweiss Evrard, Dianpeng Wang, John M Humphrey, Todd W Butler, Lise R Hoth, Jeffrey B Sperry, Sylvie K Sakata, Christopher J Helal, Christopher W Am Ende
Introduction of a Crystalline, Shelf-Stable Reagent for the Synthesis of Sulfur(VI) Fluorides. Organic letters 20 (3) (2018)
John M Humphrey, Matthew Movsesian, Christopher W Am Ende, Stacey L Becker, Thomas A Chappie, Stephen Jenkinson, Jennifer L Liras, Spiros Liras, Christine Orozco, Jayvardhan Pandit, Felix F Vajdos, Fabrice Vandeput, Eddie Yang, Frank S Menniti
Discovery of Potent and Selective Periphery-Restricted Quinazoline Inhibitors of the Cyclic Nucleotide Phosphodiesterase PDE1. Journal of medicinal chemistry 61 (10) (2018)
Christopher R Butter, Elizabeth M Beck, Anthony Harris, Zhen Huang, Laura A McAllister, Christopher W Am Ende, Kimberly Fennell, Timothy L Foley, Kari Fonseca, Steven J Hawrylik, Douglas S Johnson, John D Knafels, Scot Mente, G Stephen Noell, Jayvardhan Pandit, Tracy B Phillips, Justin R Piro, Bruce N Rogers, Tarek A Samad, Jane Wang, Shuangyi Wan, Michael A Brodney
Azetidine and Piperidine Carbamates as Efficient, Covalent Inhibitors of Monoacylglycerol Lipase. Journal of medicinal chemistry 60 (23) (2017)

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Publication Activity (10 Years)

Top Topics

Top Venues

Christopher W Am Ende