BTK inhibition is a potent approach to block IgE-mediated histamine release in human basophils.
Dubravka SmiljkovicK BlattG StefanzlY DorofeevaC SkrabsM Focke-TejklW R SperrU JaegerRudolph ValentaP ValentPublished in: Allergy (2017)
BTK-targeting drugs are potent inhibitors of IgE-dependent histamine release in human basophils. The clinical value of BTK inhibition in the context of allergic diseases remains to be determined.