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BTK inhibition is a potent approach to block IgE-mediated histamine release in human basophils.

Dubravka SmiljkovicK BlattG StefanzlY DorofeevaC SkrabsM Focke-TejklW R SperrU JaegerRudolph ValentaP Valent
Published in: Allergy (2017)
BTK-targeting drugs are potent inhibitors of IgE-dependent histamine release in human basophils. The clinical value of BTK inhibition in the context of allergic diseases remains to be determined.
Keyphrases
  • tyrosine kinase
  • endothelial cells
  • induced pluripotent stem cells
  • pluripotent stem cells
  • anti inflammatory