Reducing microtubule detyrosination improves heart function in HCM mice and human iPSC-engineered heart tissues.

Niels PietschChristina Yingxian ChenSvenja KupschLucas BacmeisterBirgit GeertzMarisol Herera-RiveroHanna VoßElisabeth KrämerIngke BrarenDirk WestermannHartmut SchlüterGiulia MeariniSaskia Schlossarek Jolanda van der VeldenMatthew A CaporizzoDiana LindnerBenjamin L Prosser Lucie Carrier

Published in: bioRxiv : the preprint server for biology (2023)

This study provides evidence that reducing dTyr-tub improves function in HCM mouse hearts and human EHTs and holds promise for targeting the non-sarcomeric cytoskeleton in heart disease.

Keyphrases

endothelial cells
induced pluripotent stem cells
hypertrophic cardiomyopathy
heart failure
pluripotent stem cells
gene expression
pulmonary hypertension
atrial fibrillation
insulin resistance
metabolic syndrome
cancer therapy
deep learning