CYP2D6 Predicts Plasma Donepezil Concentrations in a Cohort of Thai Patients with Mild to Moderate Dementia.
Monpat ChamnanphonSorawit WainipitapongTeeravut WiwattarangkulPhenphichcha ChuchuenKunathip NissaipanWeeraya PhaisalSookjaroen TangwongchaiChonlaphat SukasemSupeecha WittayalertpanyaAndrea GaedigkDaruj AniwattanapongPajaree ChariyavilaskulPublished in: Pharmacogenomics and personalized medicine (2020)
Plasma donepezil concentration in NMs was lower compared to IMs. Additional studies with larger sample size and use of next-generation sequencing as well as its outcomes are warranted to confirm the benefit of using pharmacogenetic-guided treatment for donepezil.