Clinical characteristics of HIV-1-infected patients with high levels of plasma interferon-γ: a multicenter observational study.
Dai WatanabeTomoko UehiraSachiko SuzukiErina MatsumotoTakashi UejiKazuyuki HirotaRumi MinamiSoichiro TakahamaKimikazu HayashiMorio SawamuraMasahiro YamamotoTakuma ShirasakaPublished in: BMC infectious diseases (2019)
We concluded that HIV-1-infected patients with high levels of circulating IFN-γ did not have a higher rate of comorbidities related to immune activation. However, they exhibited lower CD4+ cell count recovery after 4 years of being on ART. This deficit could be a consequence of persistent immune activation.