Distinct biological property of tau in tau-first cognitive proteinopathy: Evidence by longitudinal clinical neuroimaging profiles and compared with late-onset Alzheimer disease.

Hsin-I ChangChi-Wei HuangShu-Hua HuangShih-Wei HsuKun-Ju LinTsung-Ying HoHsiu-Chuan WuChiung-Chih Chang

Published in: Psychiatry and clinical neurosciences (2024)

The biological properties of tau and the longitudinal cognitive-imaging trajectory support the conceptual distinction between TCP and LOAD. TCP represents one specific entity featuring salient short-term memory impairment, declines in nonexecutive domains, a slower gray matter degenerative pattern, and a restricted impact of tau.

Keyphrases

late onset
cerebrospinal fluid
early onset
high resolution
cross sectional
working memory