FXR overexpression prevents hepatic steatosis through inhibiting AIM2 inflammasome activation in alcoholic liver disease.

Lin LiLina KongShuai XuChangyuan WangJiangning GuHaifeng LuoQiang Meng

Published in: Hepatology international (2024)

FXR attenuated lipid metabolism disorders and lipid degeneration in alcohol-caused liver injury and alleviated oxidative stress and inflammation by inhibiting AIM2 inflammasome activation.

Keyphrases

liver injury
drug induced
oxidative stress
signaling pathway
fatty acid
dna damage
cell proliferation
ischemia reperfusion injury
induced apoptosis
transcription factor
diabetic rats
mouse model
heat stress
heat shock
endoplasmic reticulum stress
heat shock protein