Dickkopf-related protein 1, a new biomarker for local immune status and poor prognosis among patients with colorectal liver Oligometastases: a retrospective study.
Qiaoqi SuiJian ZhengDingxin LiuJianhong PengQingjian OuJinghua TangYuan LiLingheng KongWu JiangBinyi XiaoXue ChaoZhizhong PanHuizhong ZhangPei-Rong DingPublished in: BMC cancer (2019)
Elevated serum DKK1 level was associated with poorer RFS and OS, and less CD8+ TILs in invasive margin in CRC liver oligometastases. DKK1 might serve as a supplementalprognostic factor for clinical risk score and a potential target for immunotherapy.