Acute cigarette smoke-induced eQTL affects formyl peptide receptor expression and lung function.

Simon D PouwelsValerie R WiersmaImmeke E FokkemaMarijn BergNick H T Ten HackenMaarten van den BergeIrene HeijinkAlen Faiz

Published in: Respirology (Carlton, Vic.) (2020)

We identified a novel smoking-related inducible eQTL that is associated with a smoke-induced increase in the expression of FPR1, FPR2 and FPR3, and with lowered lung function. in vitro FPR1 down-regulation protects against smoke-induced reduction in lung epithelial repair.

Keyphrases

lung function
cystic fibrosis
high glucose
chronic obstructive pulmonary disease
drug induced
diabetic rats
air pollution
poor prognosis
oxidative stress
binding protein