Double-blind, randomised placebo-controlled clinical trial of metformin as an adjunct to a sleep-wake, activity and metabolically focused behavioural intervention to improve cardiometabolic outcomes and mood symptoms in youth with major mood syndromes: study protocol.
Chloe E WilsonJoanne Sarah CarpenterAlissa NichlesNatalia ZmicerevskaYun Ju Christine SongCatherine M McHughBlake HamiltonSamuel HockeyJacob J CrouseDagmar KoetheElizabeth M ScottIan B HickiePublished in: BMJ open (2023)
Australian New Zealand Clinical Trials Registry (ANZCTR) Number: ACTRN12619001559101p, 12 November 2019.
Keyphrases
- clinical trial
- double blind
- placebo controlled
- sleep quality
- study protocol
- bipolar disorder
- phase ii
- physical activity
- randomized controlled trial
- phase iii
- depressive symptoms
- open label
- mental health
- phase ii study
- young adults
- adipose tissue
- insulin resistance
- type diabetes
- squamous cell carcinoma
- radiation therapy
- skeletal muscle