Regional redistribution of CB1 cannabinoid receptors in human foetal brains with Down's syndrome and their functional modifications in Ts65Dn +/+ mice.

Ágoston PatthyJános HanicsGergely ZacharGábor G KovácsTibor HarkanyAlán Alpár

Published in: Neuropathology and applied neurobiology (2023)

We suggest that neuroarchitectural impairments in Down's syndrome brains involve the delayed development and errant functions of the endocannabinoid system, with a particular impact on endocannabinoids modulating axonal wiring.

Keyphrases

endothelial cells
case report
spinal cord injury
signaling pathway
type diabetes
high fat diet induced
metabolic syndrome
pluripotent stem cells
gestational age