Endosialin-positive CAFs promote hepatocellular carcinoma progression by suppressing CD8 + T cell infiltration.

Lunbiao Gan Tong Lu Yu Lu Hongtao Song Jiayu Zhang Keying Zhang Shiqi Lu Xinjie Wu Fengze Nie Sijia Di Donghui Han Fa Yang Weijun Qin Weihong Wen

Published in: Journal for immunotherapy of cancer (2024)

T cell infiltration by inhibiting the expression and secretion of CXCL9/10 in CAFs, thus promote HCC progression. Combination therapy with endosialin antibody could increase the antitumor effect of PD-1 antibody in HCC, which may overcome the resistance to PD-1 blockade.

Keyphrases

combination therapy
poor prognosis
signaling pathway
binding protein
long non coding rna