A highly selective humanized DDR1 mAb reverses immune exclusion by disrupting collagen fiber alignment in breast cancer.
Junquan LiuHuai-Chin ChiangWei XiongVictor LaurentSamuel C GriffithsJasmin DülferHui DengXiujie SunY Whitney YinWenliang LiLaurent P AudolyZhiqiang AnThomas SchürpfRong LiNingyan ZhangPublished in: Journal for immunotherapy of cancer (2023)
This study not only paves a pathway for the development of PRTH-101 as a cancer therapeutic, but also sheds light on a new therapeutic strategy to modulate collagen alignment in the tumor ECM for enhancing antitumor immunity.