Unraveling the diversity and functions of tissue-resident plasma cells.
Tellier JIlariya TarasovaJunli NieChristopher S SmilliePasquale L FedeleWang H J CaoJoanna R GroomGabrielle T BelzDeepta BhattacharyaAaron T L LunStephen L NuttPublished in: Nature immunology (2024)
Antibody-secreting plasma cells (PCs) are generated in secondary lymphoid organs but are reported to reside in an emerging range of anatomical sites. Analysis of the transcriptome of different tissue-resident (Tr)PC populations revealed that they each have their own transcriptional signature indicative of functional adaptation to the host tissue environment. In contrast to expectation, all TrPCs were extremely long-lived, regardless of their organ of residence, with longevity influenced by intrinsic factors like the immunoglobulin isotype. Analysis at single-cell resolution revealed that the bone marrow is unique in housing a compendium of PCs generated all over the body that retain aspects of the transcriptional program indicative of their tissue of origin. This study reveals that extreme longevity is an intrinsic property of TrPCs whose transcriptome is imprinted by signals received both at the site of induction and within the tissue of residence.
Keyphrases
- single cell
- induced apoptosis
- rna seq
- bone marrow
- gene expression
- quality improvement
- cell cycle arrest
- magnetic resonance
- mesenchymal stem cells
- genome wide
- transcription factor
- patient safety
- climate change
- endoplasmic reticulum stress
- cell proliferation
- dna methylation
- mental health
- mass spectrometry
- single molecule
- contrast enhanced