Maternal Hypertension Increases Risk of Preeclampsia and Low Fetal Birthweight: Genetic Evidence From a Mendelian Randomization Study.

Maddalena Ardissino Eric A W SlobOphelia MillarRohin K ReddyLaura LazzariKiran Haresh Kumar PatelDavid RyanMark R JohnsonDipender Gill Fu Siong Ng

Published in: Hypertension (Dallas, Tex. : 1979) (2022)

Our results provide evidence for causal effects of SBP, body mass index, and type 2 diabetes on PET and identify that SBP is associated with reduced birthweight independently of PET. The results provide insight into the pathophysiological basis of PET and identify hypertension as a potentially modifiable risk factor amenable to therapeutic intervention.

Keyphrases

pet ct
positron emission tomography
blood pressure
type diabetes
computed tomography
pet imaging
randomized controlled trial
risk factors
gestational age
pregnancy outcomes
early onset
genome wide
gene expression
adipose tissue
metabolic syndrome
physical activity
weight gain