The Y-linked proto-oncogene TSPY contributes to poor prognosis of the male hepatocellular carcinoma patients by promoting the pro-oncogenic and suppressing the anti-oncogenic gene expression.

Published in: Cell & bioscience (2019)

We demonstrate that TSPY could exacerbate the oncogenesis of HCC by differentially upregulate the expression of pro-oncogenic genes and downregulate those of anti-oncogenic genes in male HCC patients, thereby contributing to the male predominance in this deadly cancer.

Keyphrases

poor prognosis
end stage renal disease
gene expression
chronic kidney disease
ejection fraction
transcription factor
prognostic factors
genome wide
squamous cell carcinoma
patient reported outcomes
signaling pathway
binding protein
genome wide analysis