ICOS Gene Polymorphisms (IVS1 + 173 T/C and c. 1624 C/T) in Primary Sjögren's Syndrome Patients: Analysis of ICOS Expression.

José Antonio García-Espinoza José Francisco Munoz-ValleMariel García-ChagollánJorge Hernández-Bello Claudia Azucena Palafox-SánchezErika Fabiola López-VillalobosGabriela Athziri Sánchez-ZunoGloria Esther Martínez-BonillaSergio Cerpa-CruzFrancisco Josue Carrillo-BallesterosEdith Oregon-Romero

Published in: Current issues in molecular biology (2022)

The IVS1 + 173 polymorphism is not a genetic marker for the development of pSS, while c.1624 T allele was associated with a low risk. However, elevated mICOS expression in pSS patients with high lymphocytic infiltration was found. ICOS may have an important role in the immunopathogenesis of pSS and should be analyzed in T cell subsets in pSS patients as a possible disease marker.

Keyphrases

end stage renal disease
ejection fraction
chronic kidney disease
poor prognosis
peritoneal dialysis
gene expression
patient reported outcomes
rheumatoid arthritis
dna methylation
genome wide
patient reported
case report
copy number