AMPK activation modulates IL-36-induced inflammatory responses by regulating IκBζ expression in the skin.

Yi-Ting HuangLing-Ya ChiuPo-Hsuan LuPa-Fan HsiaoJen-Yu WangPing-Hsun LuNan-Lin Wu

Published in: British journal of pharmacology (2024)

AMPK activation suppresses IL-36-induced IL-8 and CCL20 release by regulating IκBζ expression in keratinocytes and reduces IL-36-induced skin inflammation in mice, suggesting that AMPK activation is a potential strategy for treating patients with IL-36-mediated inflammatory skin disorders.

Keyphrases

high glucose
diabetic rats
oxidative stress
poor prognosis
drug induced
skeletal muscle
wound healing
liver injury
signaling pathway
type diabetes
protein kinase
endothelial cells
metabolic syndrome
binding protein
risk assessment
climate change
high fat diet induced