Molecular insights into pathogenesis and targeted therapy of peripheral T cell lymphoma.
Caiqin XieXian LiHui ZengWeidong HanPublished in: Experimental hematology & oncology (2020)
Peripheral T-cell lymphomas (PTCLs) are biologically and clinically heterogeneous diseases almost all of which are associated with poor outcomes. Recent advances in gene expression profiling that helps in diagnosis and prognostication of different subtypes and next-generation sequencing have given new insights into the pathogenesis and molecular pathway of PTCL. Here, we focus on a broader description of mutational insights into the common subtypes of PTCL including PTCL not other specified type, angioimmunoblastic T-cell lymphoma, anaplastic large cell lymphoma, and extra-nodal NK/T cell lymphoma, nasal type, and also present an overview of new targeted therapies currently in various stages of clinical trials.
Keyphrases
- clinical trial
- genome wide
- copy number
- single cell
- genome wide identification
- chemotherapy induced
- single molecule
- lymph node
- cell therapy
- neoadjuvant chemotherapy
- squamous cell carcinoma
- randomized controlled trial
- dna methylation
- radiation therapy
- metabolic syndrome
- mesenchymal stem cells
- phase ii
- transcription factor
- weight loss
- insulin resistance
- circulating tumor
- double blind