High-fat and high-glucose microenvironment decreases Runx2 and TAZ expression and inhibits bone regeneration in the mouse.

Xuan WuYunpeng ZhangYixiao XingBin ZhaoCong ZhouYong WenXin Xu

Published in: Journal of orthopaedic surgery and research (2019)

In conclusion, these results suggest that high-fat and high-glucose microenvironment inhibits bone regeneration, which may be related to the inhibition of Runx2 and TAZ expression.

Keyphrases

high glucose
bone regeneration
endothelial cells
poor prognosis
stem cells
transcription factor
binding protein