Electroacupuncture Regulates Disorders of Gut-Brain Interaction by Decreasing Corticotropin-Releasing Factor in a Rat Model of IBS.

Ying ChenYan ZhaoDan-Ni Luo Hui Zheng Ying Li Si-Yuan Zhou

Published in: Gastroenterology research and practice (2019)

EA treatment can decrease the expression of hypothalamic CRF and CRF-R1, relieve anxiety and depression, meanwhile reduce the expression of CRF-R1 in the gastrointestinal mucosa, increase ZO-1 expression, and adjust tight junctions (TJs) to repair the intestinal mucosal barrier. The above roles suggest that EA may play a dual role in alleviating the gastrointestinal and psychological symptoms of IBS, suggesting a potentially dual therapeutic role for EA in regulating disorders of gut-brain interaction in IBS rats.

Keyphrases

poor prognosis
irritable bowel syndrome
binding protein
white matter
long non coding rna
neuropathic pain
sleep quality
multiple sclerosis
spinal cord injury
spinal cord
single molecule
physical activity
combination therapy
functional connectivity