Elevated leptin levels in temporomandibular joint osteoarthritis promote proinflammatory cytokine IL-6 expression in synovial fibroblasts.

Haofei XiongWei LiJiajie LiWei FangJin KeBo LiYong Cheng Lili Wei

Published in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2019)

Leptin may up-regulate IL-6 production in vitro by binding with Ob-Rb in TMJ-SFs via the activation of the JAK2/STAT3, p38 MAPK or PI3K/Akt signalling pathways.

Keyphrases

pi k akt
signaling pathway
cell cycle arrest
cell proliferation
poor prognosis
binding protein
rheumatoid arthritis
extracellular matrix
long non coding rna
transcription factor