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Childhood sleep duration modifies the polygenic risk for obesity in youth through leptin pathway: the Beijing Child and Adolescent Metabolic Syndrome cohort study.

Junling FuYonghui WangGe LiLanwen HanYu LiLujiao LiDan FengYunpeng WuXinhua XiaoMingyao LiStruan F A GrantMing LiShan Gao
Published in: International journal of obesity (2005) (2019)
This study suggests that shorter sleep duration in children from China (< 8h/day), compared to longer sleep duration (≥10 h/day), has a long-term impact on the association of polygenic risk for obesity from childhood to young adulthood and leptin pathway explains a key mechanism via a modification effect. Therefore, adequate sleep duration during childhood is important for the early prevention of obesity, especially if there is a genetic predisposition to this trait.
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