Mitragynine (Kratom)-Withdrawal behaviour and cognitive impairments can be ameliorated by an epigenetic mechanism.

Suleiman YunusaChristian P MüllerZurina Hassan

Published in: British journal of pharmacology (2024)

The data from this work show that changes in histone expression and downstream hippocampal plasticity may explain mitragynine, but not morphine, withdrawal behaviours and cognitive impairments. Thus, it may provide a new treatment approach for aversive Kratom/mitragynine withdrawal and addiction.

Keyphrases

dna methylation
poor prognosis
gene expression
electronic health record
big data
binding protein
combination therapy
deep learning
artificial intelligence
temporal lobe epilepsy