Direct and BMI-mediated effect of birthweight on childhood cardio-metabolic health-a birth cohort study.
Maria João FonsecaMilton SeveroDebbie A LawlorHenrique BarrosAna Cristina SantosPublished in: International journal of obesity (2005) (2019)
Positive BMI-mediated effect of birthweight on all cardio-metabolic traits was found. However, direct effects were in the opposite direction, significant for blood pressure, which may explain the diversity of results observed in the literature. Combining the direct and BMI-mediated effects, higher birthweight was associated with lower blood pressure at age 7 and have no effect on other cardio-metabolic traits.