Association of Lipid Mediators With Development of Future Incident Inflammatory Arthritis in an Anti-Citrullinated Protein Antibody-Positive Population.

Kristen J PolinskiElizabeth A BemisFan YangTessa CrumeM Kristen DemoruelleMarie FeserJennifer SeifertJames R O'DellTed R MikulsMichael H WeismanPeter K GregersenRichard M KeatingJane BucknerNichole ReisdorphKevin D DeaneMichael Clare-SalzlerV Michael HolersJill M Norris

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2021)

In a prospective cohort of anti-CCP-positive individuals, higher levels of 5-HETE, an important precursor to proinflammatory leukotrienes, is associated with subsequent IA. Our findings highlight the potential significance of these PUFA metabolites in pre-RA populations.

Keyphrases

rheumatoid arthritis
cardiovascular disease
oxidative stress
current status
protein protein
disease activity
type diabetes
fatty acid
systemic lupus erythematosus
climate change
small molecule
binding protein
idiopathic pulmonary fibrosis