Non-hematopoietic IL-4Rα expression contributes to fructose-driven obesity and metabolic sequelae.
Michelle S M A DamenTraci E StankiewiczSe-Hyung ParkRobert N HelsleyCalvin C ChanMaria E Moreno-FernandezJessica R DollSara SzaboDe'Broski R HerbertSamir SofticSenad DivanovicPublished in: International journal of obesity (2005) (2021)
Our findings highlight potential contribution of non-hematopoietic IL-4Rα activation of a non-canonical signaling pathway that regulates the HF + HC diet-driven induction of obesity and severity of obesity-associated sequelae.