Long Non-Coding RNA in Vascular Disease and Aging.
Diewertje Ilse BinkNoelia Lozano-VidalReinier A BoonPublished in: Non-coding RNA (2019)
Cardiovascular diseases are the most prominent cause of death in Western society, especially in the elderly. With the increasing life expectancy, the number of patients with cardiovascular diseases will rise in the near future, leading to an increased healthcare burden. There is a need for new therapies to treat this growing number of patients. The discovery of long non-coding RNAs has led to a novel group of molecules that could be considered for their potential as therapeutic targets. This review presents an overview of long non-coding RNAs that are regulated in vascular disease and aging and which might therefore give insight into new pathways that could be targeted to diagnose, prevent, and/or treat vascular diseases.
Keyphrases
- long non coding rna
- poor prognosis
- cardiovascular disease
- healthcare
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- small molecule
- peritoneal dialysis
- prognostic factors
- south africa
- cardiovascular risk factors
- middle aged
- high throughput
- coronary artery disease
- social media
- human health
- cardiovascular events