Neurocognitive Impairment in Ugandan Children with Sickle Cell Disease Compared to Sibling Controls: A cross-sectional study.

Neurocognitive testing in a sample of children with SCA compared to non-SCA siblings revealed poorer SCA-associated neurocognitive functioning which worsened with age. Risk from age, prior stroke and elevated TCD were seen, along with effects from low hemoglobin and caretaker education. These neurocognitive effects suggest need for intervention trials using disease-modifying therapy.