Isoprenoids responsible for protein prenylation modulate the biological effects of statins on pancreatic cancer cells.

Helena GbelcováSilvie RimpelováZdeněk KnejzlíkJana ŠáchováMichal KolářHynek StrnadVanda RepiskáWalter Cosimo D'AcuntoTomáš RumlLibor Vítek

Published in: Lipids in health and disease (2017)

Our data indicate that the anticancer effects of statins observed in numerous studies to a large extent are mediated through isoprenoid intermediates of the mevalonate pathway, as they influence expression of genes involved in multiple intracellular pathways.

Keyphrases

cardiovascular disease
poor prognosis
binding protein
electronic health record
big data
protein protein
amino acid
type diabetes
long non coding rna
data analysis
small molecule
deep learning