Our data demonstrate that PNE leads to perturbation of male spermatogenesis, and the observed effects are associated with changes of peripheral nervous system signaling pathways. Alterations in the expression of genes associated with diverse biological activities such as cell migration, cell adhesion and GABA signaling in the pituitary gland underscore the complexity of the effects of nicotine exposure during pregnancy.
Keyphrases
- cell migration
- cell adhesion
- smoking cessation
- signaling pathway
- poor prognosis
- dna methylation
- gene expression
- pregnant women
- oxidative stress
- genome wide
- electronic health record
- chemotherapy induced
- binding protein
- long non coding rna
- pi k akt
- transcription factor
- induced apoptosis
- genome wide identification
- germ cell
- genome wide analysis