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Characterization of KIR + NKG2A + Eomes- NK-like CD8+ T cells and their decline with age in healthy individuals.

Dimitri KasakovskiXiangbo ZengJing LaiZhi YuDanlin YaoShaohua ChenXianfeng ZhaYangqiu LiLing Xu
Published in: Cytometry. Part B, Clinical cytometry (2020)
Overall, the KIR+NKG2A + Eomes- CD8+ T-cell population shares similar characteristics with the Eomes+ population, although with a lower degree of differentiation, lower senescence marker expression, and a proportional decrease with age. Thus, we suspect that KIR+NKG2A + Eomes-CD8+ T cells may represent a less differentiated stage of the NK-like CD8+ T-cell subset.
Keyphrases
  • nk cells
  • natural killer cells
  • poor prognosis
  • endothelial cells
  • dna damage
  • long non coding rna