Cathelicidin-deficient mice exhibit increased survival and upregulation of key inflammatory response genes following cecal ligation and puncture.
Patricia SeverinoSuely Kubo ArigaHermes Vieira BarbeiroThais Martins de LimaElisangela de Paula SilvaDenise Frediani BarbeiroMarcel Cerqueira César MachadoVictor NizetFabiano Pinheiro da SilvaPublished in: Journal of molecular medicine (Berlin, Germany) (2017)
The role of cathelicidin in a CLP model is investigated using cathelicidin-KO mice. Cathelicidin-KO mice show an enhanced immune response and improved survival rates. An anti-inflammatory effect of cathelicidin is likely to be detrimental for CLP. Cathelicidin-KO mice show upregulation of genes associated with increased plasma levels of pro-inflammatory Ils. Cathelicidins appear to have both pro- and anti-inflammatory properties.