Clinical value and potential mechanisms of COL8A1 upregulation in breast cancer: a comprehensive analysis.

Wei PengJian-Di LiJing-Jing ZengXiao-Ping ZouDeng TangWei TangMin-Hua RongYing LiWen-Bin DaiZhong-Qing TangZhen-Bo FengGang Chen

Published in: Cancer cell international (2020)

Elevated COL8A1 may promote the migration of breast cancer by mediating the ECM-receptor interaction and synergistically interplaying with DEGs and its positively related CEGs independently of molecular subtypes. Several genes clustered in the proteoglycans in cancer pathway are potential targets for developing effective agents for triple-negative breast cancer.

Keyphrases

papillary thyroid
cell proliferation
human health
poor prognosis
squamous cell
childhood cancer
gene expression
squamous cell carcinoma
single molecule
extracellular matrix
risk assessment
dna methylation
transcription factor
drug induced