Reduced expression of hematopoietic progenitor kinase 1 in T follicular helper cells causes autoimmunity of systemic lupus erythematosus.

Huilin ZhangYuming XieJunke HuangDanhong LuoQing Zhang

Published in: Lupus (2021)

Our results suggest for the first time that inhibited expression of HPK1 in SLE Tfh cells leading to Tfh cells overactivation and B cells overstimulation, subsequently, the onset and progression of SLE.

Keyphrases

systemic lupus erythematosus
induced apoptosis
cell cycle arrest
poor prognosis
disease activity
bone marrow
oxidative stress
dendritic cells
signaling pathway
regulatory t cells
binding protein
tyrosine kinase
pi k akt