New and effective EGFR-targeted fluorescence imaging technology for intraoperative rapid determination of lung cancer in freshly isolated tissue.
Changjian LiJiahui MiYueqi WangZeyu ZhangXiaoyong GuoJian ZhouZhenhua HuZhenyu ZhangPublished in: European journal of nuclear medicine and molecular imaging (2022)
By using fluorescently labeled anti-human EGFR recombinant antibody scFv fragment to incubate freshly isolated tissues during surgery, the probes can quickly accumulate in lung cancer tissues, which can be used to quickly identify tumor areas in the resected lung tissues and distinguish tumor boundaries and find metastases in lymph nodes. This technology is expected to be used for rapid intraoperative pathological detection and margin determination.
Keyphrases
- fluorescence imaging
- lymph node
- loop mediated isothermal amplification
- small cell lung cancer
- gene expression
- epidermal growth factor receptor
- photodynamic therapy
- tyrosine kinase
- endothelial cells
- minimally invasive
- patients undergoing
- molecularly imprinted
- cancer therapy
- coronary artery bypass
- sensitive detection
- acute coronary syndrome
- computed tomography
- sentinel lymph node
- percutaneous coronary intervention
- early stage
- label free
- mass spectrometry
- quantum dots
- drug delivery
- pluripotent stem cells
- pet ct