DDR1 methylation is associated with bipolar disorder and the isoform expression and methylation of myelin genes.
Beatriz Garcia-RuizManuel Castro de MouraGerard MuntanéLourdes MartorellElena BoschManel EstellerErick Jorge Canales-RodríguezEdith Pomarol-ClotetEsther JiménezEduard VietaElisabet VilellaPublished in: Epigenomics (2021)
Aim: To investigate DDR1 methylation in the brains of bipolar disorder (BD) patients and its association with DDR1 mRNA levels and comethylation with myelin genes. Materials & methods: Genome-wide profiling of DNA methylation (Infinium MethylationEPIC BeadChip) corrected for glial composition and DDR1 gene expression analysis in the occipital cortices of individuals with BD (n = 15) and healthy controls (n = 15) were conducted. Results: DDR1 5-methylcytosine levels were increased and directly associated with DDR1b mRNA expression in the brains of BD patients. We also observed that DDR1 was comethylated with a group of myelin genes. Conclusion: DDR1 is hypermethylated in BD brain tissue and is associated with isoform expression. Additionally, DDR1 comethylation with myelin genes supports the role of this receptor in myelination.
Keyphrases
- genome wide
- dna methylation
- bipolar disorder
- end stage renal disease
- genome wide identification
- copy number
- white matter
- newly diagnosed
- chronic kidney disease
- ejection fraction
- poor prognosis
- peritoneal dialysis
- binding protein
- major depressive disorder
- gene expression
- prognostic factors
- bioinformatics analysis
- patient reported outcomes
- brain injury
- blood brain barrier
- single cell
- functional connectivity
- subarachnoid hemorrhage