Antiresorptive Medications Prior to Stereotactic Body Radiotherapy for Spinal Metastasis are Associated with Reduced Incidence of Vertebral Body Compression Fracture.

Palak P PatelEdward P EspositoJiafeng ZhuXuguang ChenMajid KhanLawrence KleinbergDaniel LubelskiNicholas TheodoreSheng-Fu Larry LoSang Hun LeeKhaled M KebaishAli BydonKristin J Redmond

Published in: Global spine journal (2023)

Initiating antiresorptive agents before SBRT may reduce the risk of treatment-induced VCF. Antiresorptive drugs are underutilized in patients with spine metastases and may represent a useful intervention to minimize toxicity and improve long-term outcomes.

Keyphrases

radiation therapy
randomized controlled trial
early stage
oxidative stress
diabetic rats
spinal cord
locally advanced
spinal cord injury
combination therapy
postmenopausal women
smoking cessation