Docosahexaenoic acid reversed atherosclerotic changes in human endothelial cells induced by palmitic acid in vitro.
Saeede KarbasforushAlireza NourazarianMasoud DarabiReza RahbarghaziFatemeh Khaki-KhatibiÇıgır Biray AvciLeila SalimiBakiye Goker BagcaTanaz Novin BahadorAysa RezabakhshMajid KhaksarPublished in: Cell biochemistry and function (2018)
The current experiment showed that docosahexaenoic acid could reverse atherosclerotic changes in human endothelial cells induced by palmitic acid. The increased levels of interleukin-6 and prostaglandin E2 in atherosclerotic cells were returned to near-to-normal status. Gene expression analysis showed a reduced activity of genes participating in atherosclerotic endothelial cells treated by docosahexaenoic acid. The expression of genes related to cell clotting activity was also similar to that of normal cells.
Keyphrases
- endothelial cells
- induced apoptosis
- high glucose
- genome wide identification
- genome wide
- cell cycle arrest
- vascular endothelial growth factor
- fatty acid
- single cell
- stem cells
- bone marrow
- induced pluripotent stem cells
- signaling pathway
- oxidative stress
- cell therapy
- cell proliferation
- endoplasmic reticulum stress
- copy number
- newly diagnosed