Ionizable Lipid Nanoparticle-Mediated Delivery of Plasmid DNA in Cardiomyocytes.
Sérgio ScalzoAnderson Kenedy SantosHeloísa Athaydes Seabra FerreiraPedro A CostaPedro Henrique Dias Moura PrazeresNatália Jordana Alves da SilvaLays C GuimarãesMário de Morais E SilvaMarco T R Rodrigues AlvesCelso T R VianaItamar C G JesusAlice P RodriguesAlexander BirbrairAnderson Oliveira LoboFrederic FrezardMichael J MitchellSilvia GuatimosimPedro Pires Goulart GuimaraesPublished in: International journal of nanomedicine (2022)
Collectively, our results highlight the potential of LNPs as an efficient delivery vector for pDNA to cardiomyocytes. This study suggests that LNPs hold promise to improve gene therapy for treatment of cardiovascular disease.