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Immunosenescence profile and expression of the aging biomarker (p16INK4a) in testicular cancer survivors treated with chemotherapy.

Maria T BourlonHugo E VelazquezJuan HinojosaLuis OrozcoRicardo Rios-CorzoGuadalupe LimaLuis LlorenteDiego F Hernandez-RamirezFrancisco J Valentin-CortezIrene Medina-RangelYemil Atisha-Fregoso
Published in: BMC cancer (2020)
In this exploratory study, TCS showed increased expression of CDKN2A/p16INK4a and a lymphocyte phenotype that has been associated with immunosenescence. Further studies are warranted to define the clinical implications of these alterations in TCS.
Keyphrases
  • poor prognosis
  • long non coding rna
  • peripheral blood
  • locally advanced
  • squamous cell carcinoma
  • radiation therapy
  • chemotherapy induced