Macrophage-derived FGFR1 drives atherosclerosis through PLCγ-mediated activation of NF-κB inflammatory signaling pathway.

Lintao WangWu LuoSuya ZhangJunsheng ZhangLu HeYifan ShiLi GaoBaochuan WuXiaoyan NieChenghong HuXue HanChaoyong HeBiao Xu Guang Liang

Published in: Cardiovascular research (2024)

Our study provides evidence of a new FGFR1-PLCγ- NF-κB axis in macrophages in inflammatory atherosclerosis, supporting FGFR1 as a potentially therapeutic target for atherosclerosis-related diseases.

Keyphrases

signaling pathway
pi k akt
oxidative stress
cardiovascular disease
lps induced
epithelial mesenchymal transition
nuclear factor
cell proliferation
immune response